United States securities and exchange commission logo February 4, 2022 Nicholas Vita Chief Executive Officer Columbia Care Inc. 680 Fifth Ave., 24th Floor New York, NY 10019 Re: Columbia Care Inc. Amendment No. 1 to Form 10-12G Filed January 28, 2022 File No. 000-56294 Dear Mr. Vita: We have reviewed your filing and have the following comments. In some of our comments, we may ask you to provide us with information so we may better understand your disclosure. Please respond to these comments within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comments apply to your facts and circumstances, please tell us why in your response. After reviewing your response to these comments, we may have additional comments. Amendment No. 1 to Form 10-12G filed January 28, 2022 Product Selection and Offerings, page 27 1. We note your response to our prior comment 1 and your revisions on page 27. Please provide support for your statement that your product was designed to provide a slow- release, long-lasting effect as compared to other delivery methods available at the time. Non-GAAP Measures, page 147 2. In your revised disclosure you indicate that "gross margin" is a non-GAAP measure which does not appear accurate. Please revise your disclosure here and on page 25, or clarify why you believe this is true. Nicholas Vita FirstName LastNameNicholas Vita Columbia Care Inc. Comapany4,NameColumbia February 2022 Care Inc. February Page 2 4, 2022 Page 2 FirstName LastName Item 6. Executive Compensation, page 165 3. Please update to provide executive compensation disclosure for the fiscal year ended December 31, 2021. See Item 402(m) of Regulation S-K. Columbia Care, Inc., Tgs And Green Leaf Acquisitions Introduction To Unaudited Pro Forma Condensed Combined Statements Of Operations, page F- 177 4. Please revise your introductory narrative provide disclosure identifying the additional periods included for both Green Leaf and TGS Global. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. You may contact Sasha Parikh at 202-551-3627 or Kevin Vaughn at 202-551-3494 if you have questions regarding comments on the financial statements and related matters. Please contact Jordan Nimitz at 202-551-6001 or Chris Edwards at 202-551-6761 with any other questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: James Guttman